FlyBase Gene Report: Dmel\Ance

General Information

Symbol

Dmel\Ance

Species

D. melanogaster

Name

Angiotensin converting enzyme

Annotation Symbol

CG8827

Feature Type

protein_coding_gene

FlyBase ID

FBgn0012037

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

Angiotensin converting enzyme (Ance) encodes a member of the peptidyl-dipeptidase A family of zinc metallopeptidases. Ance product is an extracellular glycosylated enzyme with a broad substrate specificity, cleaving dipeptides from the carboxy terminus of oligopeptides. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

Race, ACE, BG:DS08220.3

Key Links

Genomic Location

Cytogenetic map

34E2-34E2

Sequence location

2L:13,905,645..13,909,212 [+]

Recombination map

2-50

RefSeq locus

NT_033779 REGION:13905645..13909212

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

enzyme

regulator

receptor

receptor binding

transporter

structural molecule

cytoskeletal binding

DNA binding

RNA binding

transcription factor

small molecule binding

metal ion binding

lipid binding

carbohydrate binding

other molecular_function

molecular function

cell cycle/proliferation

cell organization/biogenesis

transport/localization

development

reproduction

immune system

nervous system process

behavior

response to stimulus

signaling

gene expression

protein metabolism

DNA metabolism

small molecule metabolism

other biological_process

biological process

extracellular region

cytosol

cytoskeleton

mitochondrion

nucleus

chromosome

membrane

cell periphery

cell junction

cell projection

endomembrane system

synapse

macromolecular complex

other cellular_component

cellular component

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables metallopeptidase activity

inferred from direct assay

(Kim et al., 2003)

enables peptidyl-dipeptidase activity

inferred from direct assay

(Akif et al., 2012, Rylett et al., 2007, Bingham et al., 2006, Siviter et al., 2002, Wilson et al., 2002, Coates et al., 2000, Houard et al., 1998, Isaac et al., 1998, Williams et al., 1996, Cornell et al., 1995)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables metallopeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000828236

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR001548

(InterPro Project Members, 2004-)

enables peptidyl-dipeptidase activity

inferred from electronic annotation with InterPro:IPR001548

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in metamorphosis

inferred from expression pattern

(Siviter et al., 2002)

involved_in peptide hormone processing

inferred from direct assay

(Wilson et al., 2002, Houard et al., 1998, Isaac et al., 1998)

involved_in proteolysis

inferred from direct assay

(Akif et al., 2012, Rylett et al., 2007, Bingham et al., 2006, Siviter et al., 2002, Wilson et al., 2002, Houard et al., 1998, Isaac et al., 1998, Williams et al., 1996, Cornell et al., 1995)

involved_in response to symbiotic bacterium

inferred from expression pattern

(Xi et al., 2008)

involved_in sexual reproduction

inferred from expression pattern

(Rylett et al., 2007)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR001548

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Rylett et al., 2007, Siviter et al., 2002, Houard et al., 1998, Cornell et al., 1995)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN002575170

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR001548

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000828236

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ANGIOTENSIN-CONVERTING ENZYME-LIKE PEPTIDYL-DIPEPTIDASES

Protein Family (UniProt)

Belongs to the peptidase M2 family. (Q10714)

Protein Signatures (InterPro)

Peptidase M2, peptidyl-dipeptidase A

Summaries

Gene Model and Products

Expression Data

Gene ToolKit

The gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.

Category	Common alleles (# stocks)
Classical and Insertion Alleles
Loss of function allele
Amorphic allele
Fluorescently-tagged allele
Transgenic Constructs
UAS RNAi
UAS wild-type cDNA
Untagged genomic rescue
Fluorescently-tagged genomic rescue
Aberrations
Deficiency
Duplication

Alleles, Insertions, Transgenic Constructs, and Aberrations

Variants

Phenotypes

Orthologs

Paralogs

Human Disease Associations

Functional Complementation Data

Interactions

Pathways

Class of Gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-50

Cytogenetic map

34E2-34E2

Sequence location

2L:13,905,645..13,909,212 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

34E2-34E2

Limits computationally determined from genome sequence between P{lacW}Sos^k05224&P{lacW}RpII33^k05605 and P{lacW}l(2)34Fa^k00811&P{PZ}wb⁰⁹⁴³⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

34E-34E

(determined by in situ hybridisation)

(Tatei et al., 1995)

34A-34A

(determined by in situ hybridisation)

(Cornell et al., 1995)

Experimentally Determined Recombination Data

Location

2-50

(FlyBase, 2016)

2-45.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Other Comments

Relationship to Other Genes

Nomenclature History

Synonyms and Secondary IDs (17)

Datasets (0)

External Crossreferences and Linkouts ( 77 )

References (201)

The following external sites may use different assemblies or annotations than FlyBase.

GO Summary Ribbons

Expression Summary Ribbons

0.49

Gene ToolKit

Disease Model Summary Ribbon

Report Sections