Race, ACE, BG:DS08220.3
Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including metamorphosis; peptide hormone processing; and response to symbiotic bacterium. Located in extracellular space. Is expressed in several structures, including anlage in statu nascendi; circulatory system primordium; embryonic/larval midgut primordium; epidermis; and gut section. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme).
The gene Angiotensin converting enzyme is referred to in FlyBase by the symbol Dmel\Ance (CG8827, FBgn0012037). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (1 unique). Gene sequence location is 2L:13905645..13909212. Its molecular function is described by: metallopeptidase activity; peptidyl-dipeptidase activity. It is involved in the biological process described with: peptide hormone processing; response to symbiotic bacterium; proteolysis; metamorphosis; sexual reproduction. 20 alleles are reported. The phenotypes of these alleles manifest in: mesothoracic bristle; somatic trunk mesoderm derivative; external encapsulating structure; muscle system; adult cuticle. The phenotypic classes of alleles include: increased mortality during development; phenotype; abnormal behavior; increased mortality. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages.
Please see the JBrowse view of Dmel\Ance for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.52
2.1 (northern blot)
4.0, 2.0 (northern blot)
615 (aa); 67 (kD observed)
615 (aa)
Glycosylated.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ance using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reference states 4-12 hr AEL
The major 2kb Ance transcript is expressed throughout development but is not present in ovaries. Ance transcripts are detected in embryos by in situ hybridization in the amnioserosa from 1.5 hrs through germ band shortening. Expression is detected in the anterior and posterior midguts in germ band elongated and retracting embryos. In later embryos, expression appears in pericardial cells associated with the dorsal vessel. In zen and dpp mutants, there is a complete absence of staining in the amnioserosa but midgut expression is normal.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Ance in JBrowseThe gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.
Category | Common alleles (# stocks) |
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Classical and Insertion Alleles | |
Loss of function allele | |
Amorphic allele | |
Fluorescently-tagged allele | |
Transgenic Constructs | |
UAS RNAi | |
UAS wild-type cDNA | |
Untagged genomic rescue | |
Fluorescently-tagged genomic rescue | |
Aberrations | |
Deficiency | |
Duplication |
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Isolated from a 4-8 hour embryo cDNA library, using a fragment of a human ACE cDNA as a probe.
An Ance cDNA has been cloned.
Ance has been cloned and sequenced, and its expression pattern has been analysed.
The Coates and Levine groups published conflicting map locations and their submitted sequences conflicted in several places, but subsequent work has confirmed that their genes are the same. Clarification is in FBrf0089312.
Source for merge of: Ance anon- EST:fe3D10
Source for identity of: Ance CG8827