FlyBase Gene Report: Dmel\CD98hc

General Information

Symbol

Dmel\CD98hc

Species

D. melanogaster

Name

CD98 heavy chain

Annotation Symbol

CG2791

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037533

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Summary

CD98 heavy chain (CD98hc) encodes a transporter involved in the transmembrane import of L-leucine. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

84E6-84E6

Sequence location

3R:7,974,409..7,978,428 [-]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:7974409..7978428

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

enzyme

regulator

receptor

receptor binding

transporter

structural molecule

cytoskeletal binding

DNA binding

RNA binding

transcription factor

small molecule binding

metal ion binding

lipid binding

carbohydrate binding

other molecular_function

molecular function

cell cycle/proliferation

cell organization/biogenesis

transport/localization

development

reproduction

immune system

nervous system process

behavior

response to stimulus

signaling

gene expression

protein metabolism

DNA metabolism

small molecule metabolism

other biological_process

biological process

extracellular region

cytosol

cytoskeleton

mitochondrion

nucleus

chromosome

membrane

cell periphery

cell junction

cell projection

endomembrane system

synapse

macromolecular complex

other cellular_component

cellular component

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in L-leucine import across plasma membrane

inferred from mutant phenotype

(Reynolds et al., 2009)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in amino acid transport

inferred from electronic annotation with InterPro:IPR042280

(InterPro Project Members, 2004-)

involved_in carbohydrate metabolic process

inferred from electronic annotation with InterPro:IPR006047

(InterPro Project Members, 2004-)

involved_in L-alanine import across plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002928136

(GO Reference Genome Project, 2011-)

involved_in L-leucine import across plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002928136

(GO Reference Genome Project, 2011-)

involved_in phenylalanine transport

inferred from biological aspect of ancestor with PANTHER:PTN002928136

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cell cortex

inferred from direct assay

(Galagovsky et al., 2018)

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in apical plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002928136

(GO Reference Genome Project, 2011-)

is_active_in basolateral plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002928136

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SLC3 FAMILY OF HETEROMERIC AMINO ACID TRANSPORTERS ANCILLARY SUBUNITS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Expression Data

Gene ToolKit

The gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.

Category	Common alleles (# stocks)
Classical and Insertion Alleles
Loss of function allele
Amorphic allele
Fluorescently-tagged allele
Transgenic Constructs
UAS RNAi
UAS wild-type cDNA
Untagged genomic rescue
Fluorescently-tagged genomic rescue
Aberrations
Deficiency
Duplication

Alleles, Insertions, Transgenic Constructs, and Aberrations

Variants

Phenotypes

Orthologs

Paralogs

Human Disease Associations

Functional Complementation Data

Interactions

Pathways

Class of Gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

84E6-84E6

Sequence location

3R:7,974,409..7,978,428 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

84E6-84E6

Limits computationally determined from genome sequence between P{EP}EP3060^EP3060 and P{PZ}grn⁰⁵⁹³⁰

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-44.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Other Comments

Relationship to Other Genes

Nomenclature History

Synonyms and Secondary IDs (7)

Datasets (0)

External Crossreferences and Linkouts ( 57 )

References (57)

The following external sites may use different assemblies or annotations than FlyBase.

GO Summary Ribbons

Expression Summary Ribbons

-0.94

Gene ToolKit

Disease Model Summary Ribbon

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