FlyBase Gene Report: Dmel\Afg3l2

General Information

Symbol

Dmel\Afg3l2

Species

D. melanogaster

Name

AFG3 like matrix AAA peptidase subunit 2

Annotation Symbol

CG6512

Feature Type

protein_coding_gene

FlyBase ID

FBgn0036702

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Predicted to enable metalloendopeptidase activity. Involved in mitochondrial protein processing. Part of m-AAA complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and somatic trunk mesoderm derivative. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in optic atrophy 12; spastic ataxia; spastic ataxia 5; and spinocerebellar ataxia type 28. Orthologous to human AFG3L2 (AFG3 like matrix AAA peptidase subunit 2). (Alliance, FBgn0036702 )

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All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

74A1-74A2

Sequence location

3L:17,238,613..17,242,128 [-]

Recombination map

3-45

RefSeq locus

NT_037436 REGION:17238613..17242128

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

enzyme

regulator

receptor

receptor binding

transporter

structural molecule

cytoskeletal binding

DNA binding

RNA binding

transcription factor

small molecule binding

metal ion binding

lipid binding

carbohydrate binding

other molecular_function

molecular function

cell cycle/proliferation

cell organization/biogenesis

transport/localization

development

reproduction

immune system

nervous system process

behavior

response to stimulus

signaling

gene expression

protein metabolism

DNA metabolism

small molecule metabolism

other biological_process

biological process

extracellular region

cytosol

cytoskeleton

mitochondrion

nucleus

chromosome

membrane

cell periphery

cell junction

cell projection

endomembrane system

synapse

macromolecular complex

other cellular_component

cellular component

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000642, InterPro:IPR003959, InterPro:IPR003960, InterPro:IPR011546, InterPro:IPR037219

(InterPro Project Members, 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR003593, InterPro:IPR003959, InterPro:IPR003960

(InterPro Project Members, 2004-)

enables ATP-dependent peptidase activity

inferred from electronic annotation with InterPro:IPR000642, InterPro:IPR005936, InterPro:IPR011546, InterPro:IPR037219

(InterPro Project Members, 2004-)

enables metalloendopeptidase activity

inferred by curator from GO:0005745

(Pareek and Pallanck, 2020)

inferred from sequence or structural similarity with UniProtKB:Q9Y4W6

(Sardiello et al., 2003.6.11)

inferred from biological aspect of ancestor with PANTHER:PTN008683692

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR000642, InterPro:IPR005936, InterPro:IPR011546, InterPro:IPR037219

(InterPro Project Members, 2004-)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR011546

(InterPro Project Members, 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in mitochondrial protein processing

inferred from mutant phenotype

(Pareek and Pallanck, 2020)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in mitochondrial protein processing

inferred from biological aspect of ancestor with PANTHER:PTN000554085

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR000642, InterPro:IPR037219

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:Q9Y4W6

(Sardiello et al., 2003.6.11)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of m-AAA complex

inferred from physical interaction with FLYBASE:Spg7; FB:FBgn0024992

(Pareek and Pallanck, 2020)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of m-AAA complex

inferred from biological aspect of ancestor with PANTHER:PTN000554085

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR005936, InterPro:IPR011546

(InterPro Project Members, 2004-)

located_in mitochondrion

inferred from sequence or structural similarity with UniProtKB:Q9Y4W6

(Sardiello et al., 2003.6.11)

Gene Group (FlyBase)

ATP-DEPENDENT METALLOENDOPEPTIDASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ATP hydrolysis activity
RHEA 13065:

Summaries

Gene Model and Products

Expression Data

Gene ToolKit

The gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.

Category	Common alleles (# stocks)
Classical and Insertion Alleles
Loss of function allele
Amorphic allele
Fluorescently-tagged allele
Transgenic Constructs
UAS RNAi
UAS wild-type cDNA
Untagged genomic rescue
Fluorescently-tagged genomic rescue
Aberrations
Deficiency
Duplication

Alleles, Insertions, Transgenic Constructs, and Aberrations

Variants

Phenotypes

Orthologs

Paralogs

Human Disease Associations

Functional Complementation Data

Interactions

Pathways

Class of Gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-45

Cytogenetic map

74A1-74A2

Sequence location

3L:17,238,613..17,242,128 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

74A1-74A2

Limits computationally determined from genome sequence between P{PZ}Baldspot⁰²²⁸¹ and P{PZ}blot⁰¹⁶⁵⁸

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-45

(FlyBase, 2016)

3-40.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Other Comments

Relationship to Other Genes

Nomenclature History

Synonyms and Secondary IDs (5)

Datasets (0)

External Crossreferences and Linkouts ( 49 )

References (63)

The following external sites may use different assemblies or annotations than FlyBase.

GO Summary Ribbons

Expression Summary Ribbons

4.68

Gene ToolKit

Disease Model Summary Ribbon

Report Sections