Predicted to enable metalloendopeptidase activity. Involved in mitochondrial protein processing. Part of m-AAA complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and somatic trunk mesoderm derivative. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in optic atrophy 12; spastic ataxia; spastic ataxia 5; and spinocerebellar ataxia type 28. Orthologous to human AFG3L2 (AFG3 like matrix AAA peptidase subunit 2).
The gene AFG3 like matrix AAA peptidase subunit 2 is referred to in FlyBase by the symbol Dmel\Afg3l2 (CG6512, FBgn0036702). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (all unique). Gene sequence location is 3L:17238613..17242128. Its molecular function is described by: zinc ion binding; ATP hydrolysis activity; ATP-dependent peptidase activity; metalloendopeptidase activity; ATP binding. It is involved in the biological process described with: mitochondrial protein processing; proteolysis. 10 alleles are reported. The phenotypes of these alleles manifest in: cellular anatomical structure; cytoplasm; mitochondrion; organism; sensory system. The phenotypic classes of alleles include: viable; abnormal size; phenotype; increased mortality. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes.
Please see the JBrowse view of Dmel\Afg3l2 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.46
Gene model reviewed during 5.40
Gene model reviewed during 5.41
Gene model reviewed during 5.56
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Afg3l2 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
JBrowse - Visual display of RNA-Seq signals
View Dmel\Afg3l2 in JBrowseThe gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.
Category | Common alleles (# stocks) |
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Classical and Insertion Alleles | |
Loss of function allele | |
Amorphic allele | |
Fluorescently-tagged allele | |
Transgenic Constructs | |
UAS RNAi | |
UAS wild-type cDNA | |
Untagged genomic rescue | |
Fluorescently-tagged genomic rescue | |
Aberrations | |
Deficiency | |
Duplication |
3-45
3-40.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Afg3l2 CG6512