FB2025_01 , released February 20, 2025
Gene: Dmel\Afg3l2
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General Information
Symbol
Dmel\Afg3l2
Species
D. melanogaster
Name
AFG3 like matrix AAA peptidase subunit 2
Annotation Symbol
CG6512
Feature Type
FlyBase ID
FBgn0036702
Gene Model Status
Stock Availability
Gene Summary
Predicted to enable metalloendopeptidase activity. Involved in mitochondrial protein processing. Part of m-AAA complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and somatic trunk mesoderm derivative. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in optic atrophy 12; spastic ataxia; spastic ataxia 5; and spinocerebellar ataxia type 28. Orthologous to human AFG3L2 (AFG3 like matrix AAA peptidase subunit 2). (Alliance, FBgn0036702 )
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Genomic Location
Cytogenetic map
Sequence location
Recombination map
3-45
RefSeq locus
NT_037436 REGION:17238613..17242128
Sequence
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Function

GO Summary Ribbons

enzyme
regulator
receptor
receptor binding
transporter
structural molecule
cytoskeletal binding
DNA binding
RNA binding
transcription factor
small molecule binding
metal ion binding
lipid binding
carbohydrate binding
other molecular_function
molecular function
cell cycle/proliferation
cell organization/biogenesis
transport/localization
development
reproduction
immune system
nervous system process
behavior
response to stimulus
signaling
gene expression
protein metabolism
DNA metabolism
small molecule metabolism
other biological_process
biological process
extracellular region
cytosol
cytoskeleton
mitochondrion
nucleus
chromosome
membrane
cell periphery
cell junction
cell projection
endomembrane system
synapse
macromolecular complex
other cellular_component
cellular component
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (5 terms)
Biological Process (2 terms)
Cellular Component (3 terms)
Protein Family (UniProt)
-
Catalytic Activity (EC/Rhea)
ATP hydrolysis activity
RHEA 13065:
Summaries
Gene Model and Products
Expression Data

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Alleles, Insertions, Transgenic Constructs, and Aberrations
Variants
Phenotypes
Orthologs
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Human Disease Associations
Functional Complementation Data
Interactions
Pathways
Class of Gene
Genomic Location and Detailed Mapping Data
Stocks and Reagents
Other Comments
Relationship to Other Genes
Nomenclature History
Synonyms and Secondary IDs (5)
Datasets (0)
External Crossreferences and Linkouts ( 49 )
References (63)