DmCht2
Enables chitinase activity. Involved in several processes, including chitin catabolic process; chitin-based cuticle development; and ecdysis, chitin-based cuticle. Located in external side of apical plasma membrane and extracellular space. Is expressed in several structures, including adult head; embryonic head epidermis; epidermis; gut section; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic).
The gene Chitinase 2 is referred to in FlyBase by the symbol Dmel\Cht2 (CG2054, FBgn0022702). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (1 unique). Gene sequence location is 3L:1752328..1755934. Its molecular function is described by: chitinase activity; hydrolase activity, hydrolyzing O-glycosyl compounds; chitin binding. It is involved in the biological process described with 8 unique terms, many of which group under: multicellular organismal process; anatomical structure development; multicellular organism development; chitin-based cuticle development; cellular process. 8 alleles are reported. The phenotypes of these alleles manifest in: larval integumentary system; acellular anatomical structure; presumptive embryonic/larval tracheal system; larva; cuticular pore. The phenotypic classes of alleles include: phenotype; increased mortality during development; abnormal eclosion; increased mortality. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed during early pupal stages.
Please see the JBrowse view of Dmel\Cht2 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.43
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cht2 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: extracellular matrix of
Comment: extracellular matrix of
Comment: extracellular matrix of
Comment: extracellular matrix of
Comment: extracellular matrix of
Comment: extracellular matrix of
Cht2 protein expression is observed in the cuticle-forming organs of late embryos in the foregut, hindgut, tracheal system, epidermis, spriacles, and salivary glands. Cht2 protein is also observed in tissues that produce chitin matrices including the tracheal system, foregut, midgut, and posterior spiracles. Staining is also observed in small salivary gland cells and in imaginal disc cells. Cht2 protein is present in the newly synthesized chitin matrix of the assembly zone and in the compact chitin lamellae of the procuticle.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Cht2 in JBrowseThe gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.
Category | Common alleles (# stocks) |
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Classical and Insertion Alleles | |
Loss of function allele | |
Amorphic allele | |
Fluorescently-tagged allele | |
Transgenic Constructs | |
UAS RNAi | |
UAS wild-type cDNA | |
Untagged genomic rescue | |
Fluorescently-tagged genomic rescue | |
Aberrations | |
Deficiency | |
Duplication |
3-1.0
3-2.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Cht2 CG2054