FlyBase Gene Report: Dmel\Cht2

General Information

Symbol

Dmel\Cht2

Species

D. melanogaster

Name

Chitinase 2

Annotation Symbol

CG2054

Feature Type

protein_coding_gene

FlyBase ID

FBgn0022702

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Enables chitinase activity. Involved in several processes, including chitin catabolic process; chitin-based cuticle development; and ecdysis, chitin-based cuticle. Located in external side of apical plasma membrane and extracellular space. Is expressed in several structures, including adult head; embryonic head epidermis; epidermis; gut section; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). (Alliance, FBgn0022702 )

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All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

DmCht2

Key Links

Genomic Location

Cytogenetic map

62B1-62B1

Sequence location

3L:1,752,328..1,755,934 [-]

Recombination map

3-1.0

RefSeq locus

NT_037436 REGION:1752328..1755934

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

enzyme

regulator

receptor

receptor binding

transporter

structural molecule

cytoskeletal binding

DNA binding

RNA binding

transcription factor

small molecule binding

metal ion binding

lipid binding

carbohydrate binding

other molecular_function

molecular function

cell cycle/proliferation

cell organization/biogenesis

transport/localization

development

reproduction

immune system

nervous system process

behavior

response to stimulus

signaling

gene expression

protein metabolism

DNA metabolism

small molecule metabolism

other biological_process

biological process

extracellular region

cytosol

cytoskeleton

mitochondrion

nucleus

chromosome

membrane

cell periphery

cell junction

cell projection

endomembrane system

synapse

macromolecular complex

other cellular_component

cellular component

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables chitinase activity

inferred from mutant phenotype

(Behr and Riedel, 2020)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables chitin binding

inferred from electronic annotation with InterPro:IPR011583

(InterPro Project Members, 2004-)

enables chitinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000126545

(GO Reference Genome Project, 2011-)

enables hydrolase activity, hydrolyzing O-glycosyl compounds

inferred from electronic annotation with InterPro:IPR001579

(InterPro Project Members, 2004-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in chitin catabolic process

inferred from mutant phenotype

(Behr and Riedel, 2020)

involved_in chitin-based cuticle development

inferred from mutant phenotype

(Behr and Riedel, 2020, Pesch et al., 2016)

involved_in chitin-based embryonic cuticle biosynthetic process

inferred from mutant phenotype

(Pesch et al., 2016)

involved_in ecdysis, chitin-based cuticle

inferred from mutant phenotype

(Pesch et al., 2016)

involved_in larval chitin-based cuticle development

inferred from mutant phenotype

(Pesch et al., 2017)

involved_in regulation of tube size, open tracheal system

inferred from mutant phenotype

(Behr and Riedel, 2020)

involved_in wound healing

inferred from mutant phenotype

(Pesch et al., 2016)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in carbohydrate metabolic process

inferred from electronic annotation with InterPro:IPR001223, InterPro:IPR001579

(InterPro Project Members, 2004-)

involved_in chitin catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000126545

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in external side of apical plasma membrane

inferred from direct assay

(Behr and Riedel, 2020)

located_in extracellular space

inferred from direct assay

(Pesch et al., 2017)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular region

inferred from biological aspect of ancestor with PANTHER:PTN000126545

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CHITINASES

Pathway (FlyBase)

CHITIN CATABOLISM

Protein Family (UniProt)

Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. (Q9W092)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Expression Data

Gene ToolKit

The gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.

Category	Common alleles (# stocks)
Classical and Insertion Alleles
Loss of function allele
Amorphic allele
Fluorescently-tagged allele
Transgenic Constructs
UAS RNAi
UAS wild-type cDNA
Untagged genomic rescue
Fluorescently-tagged genomic rescue
Aberrations
Deficiency
Duplication

Alleles, Insertions, Transgenic Constructs, and Aberrations

Variants

Phenotypes

Orthologs

Paralogs

Human Disease Associations

Functional Complementation Data

Interactions

Pathways

Class of Gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-1.0

Cytogenetic map

62B1-62B1

Sequence location

3L:1,752,328..1,755,934 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62B1-62B1

Limits computationally determined from genome sequence between P{EP}rho^EP3704&P{PZ}l(3)06226⁰⁶²²⁶ and P{PZ}dlt⁰⁴²⁷⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

61F3-62B11

(determined by in situ hybridisation)

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-1.0

(FlyBase, 2016)

3-2.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Other Comments

Relationship to Other Genes

Nomenclature History

Synonyms and Secondary IDs (9)

Datasets (0)

External Crossreferences and Linkouts ( 51 )

References (61)

The following external sites may use different assemblies or annotations than FlyBase.

GO Summary Ribbons

Expression Summary Ribbons

-0.39

Gene ToolKit

Disease Model Summary Ribbon

Report Sections