FB2025_01 , released February 20, 2025
Gene: Dmel\Nxt1
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General Information
Symbol
Dmel\Nxt1
Species
D. melanogaster
Name
NTF2-related export protein 1
Annotation Symbol
CG12752
Feature Type
FlyBase ID
FBgn0028411
Gene Model Status
Stock Availability
Gene Summary
Stimulator of protein export for NES-containing proteins (By similarity). Plays a role in the nuclear export of mRNA (PubMed:14729961). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity). In ovaries, plays a role in transposable element silencing regulation (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835, PubMed:33856346). Forms a complex with nxf2, Panx and piwi which acts as effector of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835). In ovarian follicle cells, enables the nuclear export of flamenco (flam) transcripts and subsequent piRNA biogenesis (PubMed:33856346). (UniProt, Q9V3H8)
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Also Known As

p15

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
2-105
RefSeq locus
NT_033778 REGION:23811321..23811974
Sequence
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Function

GO Summary Ribbons

enzyme
regulator
receptor
receptor binding
transporter
structural molecule
cytoskeletal binding
DNA binding
RNA binding
transcription factor
small molecule binding
metal ion binding
lipid binding
carbohydrate binding
other molecular_function
molecular function
cell cycle/proliferation
cell organization/biogenesis
transport/localization
development
reproduction
immune system
nervous system process
behavior
response to stimulus
signaling
gene expression
protein metabolism
DNA metabolism
small molecule metabolism
other biological_process
biological process
extracellular region
cytosol
cytoskeleton
mitochondrion
nucleus
chromosome
membrane
cell periphery
cell junction
cell projection
endomembrane system
synapse
macromolecular complex
other cellular_component
cellular component
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (1 term)
Biological Process (4 terms)
Cellular Component (6 terms)
Protein Family (UniProt)
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Summaries
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Expression Data

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Alleles, Insertions, Transgenic Constructs, and Aberrations
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Phenotypes
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Human Disease Associations
Functional Complementation Data
Interactions
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Genomic Location and Detailed Mapping Data
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Relationship to Other Genes
Nomenclature History
Synonyms and Secondary IDs (14)
Datasets (0)
External Crossreferences and Linkouts ( 45 )
References (88)