FlyBase Gene Report: Dmel\Nxt1

General Information

Symbol

Dmel\Nxt1

Species

D. melanogaster

Name

NTF2-related export protein 1

Annotation Symbol

CG12752

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028411

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Stimulator of protein export for NES-containing proteins (By similarity). Plays a role in the nuclear export of mRNA (PubMed:14729961). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity). In ovaries, plays a role in transposable element silencing regulation (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835, PubMed:33856346). Forms a complex with nxf2, Panx and piwi which acts as effector of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835). In ovarian follicle cells, enables the nuclear export of flamenco (flam) transcripts and subsequent piRNA biogenesis (PubMed:33856346). (UniProt, Q9V3H8)

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All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

p15

Key Links

Genomic Location

Cytogenetic map

60A2-60A2

Sequence location

2R:23,811,321..23,811,974 [-]

Recombination map

2-105

RefSeq locus

NT_033778 REGION:23811321..23811974

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

enzyme

regulator

receptor

receptor binding

transporter

structural molecule

cytoskeletal binding

DNA binding

RNA binding

transcription factor

small molecule binding

metal ion binding

lipid binding

carbohydrate binding

other molecular_function

molecular function

cell cycle/proliferation

cell organization/biogenesis

transport/localization

development

reproduction

immune system

nervous system process

behavior

response to stimulus

signaling

gene expression

protein metabolism

DNA metabolism

small molecule metabolism

other biological_process

biological process

extracellular region

cytosol

cytoskeleton

mitochondrion

nucleus

chromosome

membrane

cell periphery

cell junction

cell projection

endomembrane system

synapse

macromolecular complex

other cellular_component

cellular component

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:Q9VKM1,UniProtKB:Q9VV73,UniProtKB:Q9W2H9

(Batki et al., 2019, Murano et al., 2019)

inferred from physical interaction with UniProtKB:Q9VV73,UniProtKB:Q9W2H9

(Fabry et al., 2019, Zhao et al., 2019)

inferred from physical interaction with UniProtKB:Q9U1H9

(Zhao et al., 2019)

inferred from physical interaction with UniProtKB:Q9VV73

(Zhao et al., 2019)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in defense response to Gram-negative bacterium

inferred from high throughput mutant phenotype

(Cronin et al., 2009)

involved_in negative regulation of innate immune response

inferred from high throughput mutant phenotype

(Cronin et al., 2009)

involved_in poly(A)+ mRNA export from nucleus

inferred from mutant phenotype

(Herold et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in nucleocytoplasmic transport

inferred from electronic annotation with InterPro:IPR045875

(InterPro Project Members, 2004-)

involved_in poly(A)+ mRNA export from nucleus

inferred from biological aspect of ancestor with PANTHER:PTN008540767

(GO Reference Genome Project, 2011-)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Herold et al., 2001)

located_in nuclear envelope

inferred from direct assay

(Herold et al., 2001)

located_in nucleoplasm

inferred from direct assay

(Herold et al., 2001)

located_in nucleus

inferred from direct assay

(Batki et al., 2019)

part_of transcription repressor complex

inferred from direct assay

(Fabry et al., 2019, Zhao et al., 2019)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of nuclear pore central transport channel

inferred from biological aspect of ancestor with PANTHER:PTN000289031

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

NXF1-NXT1 MRNA NUCLEAR EXPORT FACTOR COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Expression Data

Gene ToolKit

The gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.

Category	Common alleles (# stocks)
Classical and Insertion Alleles
Loss of function allele
Amorphic allele
Fluorescently-tagged allele
Transgenic Constructs
UAS RNAi
UAS wild-type cDNA
Untagged genomic rescue
Fluorescently-tagged genomic rescue
Aberrations
Deficiency
Duplication

Alleles, Insertions, Transgenic Constructs, and Aberrations

Variants

Phenotypes

Orthologs

Paralogs

Human Disease Associations

Functional Complementation Data

Interactions

Pathways

Class of Gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-105

Cytogenetic map

60A2-60A2

Sequence location

2R:23,811,321..23,811,974 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60A2-60A2

Limits computationally determined from genome sequence between P{EP}egl^EP938 and P{lacW}eIF6^k13214

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-105

(FlyBase, 2016)

2-109.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Other Comments

Relationship to Other Genes

Nomenclature History

Synonyms and Secondary IDs (14)

Datasets (0)

External Crossreferences and Linkouts ( 45 )

References (88)

The following external sites may use different assemblies or annotations than FlyBase.

GO Summary Ribbons

Expression Summary Ribbons

-0.55

Gene ToolKit

Disease Model Summary Ribbon

Report Sections