The gene Sec61 beta subunit is referred to in FlyBase by the symbol Dmel\Sec61β (CG10130, FBgn0010638). It is a protein_coding_gene from Dmel. It has one annotated transcript and one polypeptide. Gene sequence location is 2R:14618771..14619681. Its molecular function is described by: guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: post-translational protein targeting to membrane, translocation; negative regulation of autophagy; SRP-dependent cotranslational protein targeting to membrane, translocation; intracellular protein transport. 20 alleles are reported. The phenotypes of these alleles manifest in: cellular anatomical structure; larval integumentary system; prepupal integumentary system; cell periphery; segment of leg. The phenotypic classes of alleles include: majority die during embryonic stage; increased mortality during development; phenotype; increased mortality. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages.