α-COP
Predicted to enable structural molecule activity. Involved in male meiosis cytokinesis; protein localization to cleavage furrow; and regulation of lipid storage. Located in endoplasmic reticulum-Golgi intermediate compartment. Part of COPI vesicle coat. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gut section; and male germline cell. Human ortholog(s) of this gene implicated in autoimmune interstitial lung, joint, and kidney disease. Orthologous to human COPA (COPI coat complex subunit alpha).
The gene Coat Protein (coatomer) alpha is referred to in FlyBase by the symbol Dmel\αCOP (CG7961, FBgn0025725). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (1 unique). Gene sequence location is 3L:1641066..1645199. Its molecular function is described by: structural molecule activity. It is involved in the biological process described with 8 unique terms, many of which group under: cellular process; establishment of localization; Golgi vesicle transport; cellular localization; transport. 9 alleles are reported. The phenotypes of these alleles manifest in: supramolecular fiber; cellular anatomical structure; supramolecular polymer; external encapsulating structure; adult neuromuscular junction. The phenotypic classes of alleles include: viable; fertile; abnormal neuroanatomy; lethal; lethal - all die during larval stage; abnormal neurophysiology. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages, during early pupal stages, in adult female stages.
Please see the JBrowse view of Dmel\αCOP for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\αCOP using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
αCOP is localized to the endoplasmic reticulum-Golgi intermediate compartment in premeiotic spermatocytes, to COPI vesicles associated with astral microtubules in meiotic primary spermatocytes, and to the acroblast in onion stage spermatids.
JBrowse - Visual display of RNA-Seq signals
View Dmel\αCOP in JBrowseThe gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.
Category | Common alleles (# stocks) |
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Classical and Insertion Alleles | |
Loss of function allele | |
Amorphic allele | |
Fluorescently-tagged allele | |
Transgenic Constructs | |
UAS RNAi | |
UAS wild-type cDNA | |
Untagged genomic rescue | |
Fluorescently-tagged genomic rescue | |
Aberrations | |
Deficiency | |
Duplication |
3-0.5
3-2.5
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
Source for identity of: αCOP αCop