FlyBase Gene Report: Dmel\αCOP

General Information

Symbol

Dmel\αCOP

Species

D. melanogaster

Name

Coat Protein (coatomer) α

Annotation Symbol

CG7961

Feature Type

protein_coding_gene

FlyBase ID

FBgn0025725

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Predicted to enable structural molecule activity. Involved in male meiosis cytokinesis; protein localization to cleavage furrow; and regulation of lipid storage. Located in endoplasmic reticulum-Golgi intermediate compartment. Part of COPI vesicle coat. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gut section; and male germline cell. Human ortholog(s) of this gene implicated in autoimmune interstitial lung, joint, and kidney disease. Orthologous to human COPA (COPI coat complex subunit alpha). (Alliance, FBgn0025725 )

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All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

α-COP

Key Links

Genomic Location

Cytogenetic map

62A9-62A9

Sequence location

3L:1,641,066..1,645,199 [-]

Recombination map

3-0.5

RefSeq locus

NT_037436 REGION:1641066..1645199

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

enzyme

regulator

receptor

receptor binding

transporter

structural molecule

cytoskeletal binding

DNA binding

RNA binding

transcription factor

small molecule binding

metal ion binding

lipid binding

carbohydrate binding

other molecular_function

molecular function

cell cycle/proliferation

cell organization/biogenesis

transport/localization

development

reproduction

immune system

nervous system process

behavior

response to stimulus

signaling

gene expression

protein metabolism

DNA metabolism

small molecule metabolism

other biological_process

biological process

extracellular region

cytosol

cytoskeleton

mitochondrion

nucleus

chromosome

membrane

cell periphery

cell junction

cell projection

endomembrane system

synapse

macromolecular complex

other cellular_component

cellular component

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables structural molecule activity

inferred from electronic annotation with InterPro:IPR006692, InterPro:IPR010714

(InterPro Project Members, 2004-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in male meiosis cytokinesis

inferred from mutant phenotype

(Kitazawa et al., 2012)

involved_in protein localization to cleavage furrow

inferred from mutant phenotype

(Kitazawa et al., 2012)

involved_in regulation of lipid storage

inferred from direct assay

(Beller et al., 2008)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in endoplasmic reticulum to Golgi vesicle-mediated transport

inferred from electronic annotation with InterPro:IPR016391

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000458798

(GO Reference Genome Project, 2011-)

involved_in intra-Golgi vesicle-mediated transport

inferred from biological aspect of ancestor with PANTHER:PTN000458798

(GO Reference Genome Project, 2011-)

involved_in intracellular protein transport

inferred from biological aspect of ancestor with PANTHER:PTN000458798

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR006692, InterPro:IPR010714, InterPro:IPR016391

(InterPro Project Members, 2004-)

involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

inferred from biological aspect of ancestor with PANTHER:PTN000458798

(GO Reference Genome Project, 2011-)

involved_in vesicle-mediated transport

non-traceable author statement

(Sisson et al., 2000)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of COPI vesicle coat

inferred from direct assay

(Stuart et al., 2007)

located_in endoplasmic reticulum-Golgi intermediate compartment

inferred from direct assay

(Kitazawa et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of COPI vesicle coat

inferred from biological aspect of ancestor with PANTHER:PTN000458798

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR010714, InterPro:IPR016391

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

COAT PROTEIN COMPLEX I

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Expression Data

Gene ToolKit

The gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.

Category	Common alleles (# stocks)
Classical and Insertion Alleles
Loss of function allele
Amorphic allele
Fluorescently-tagged allele
Transgenic Constructs
UAS RNAi
UAS wild-type cDNA
Untagged genomic rescue
Fluorescently-tagged genomic rescue
Aberrations
Deficiency
Duplication

Alleles, Insertions, Transgenic Constructs, and Aberrations

Variants

Phenotypes

Orthologs

Paralogs

Human Disease Associations

Functional Complementation Data

Interactions

Pathways

Class of Gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-0.5

Cytogenetic map

62A9-62A9

Sequence location

3L:1,641,066..1,645,199 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62A9-62A9

Limits computationally determined from genome sequence between P{EP}rho^EP3704&P{PZ}l(3)06226⁰⁶²²⁶ and P{PZ}dlt⁰⁴²⁷⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

62A10-62B5

(determined by in situ hybridisation)

(Merdes, 1998.12.20)

Experimentally Determined Recombination Data

Location

3-0.5

(FlyBase, 2016)

3-2.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Other Comments

Relationship to Other Genes

Nomenclature History

Synonyms and Secondary IDs (11)

Datasets (0)

External Crossreferences and Linkouts ( 52 )

References (87)

The following external sites may use different assemblies or annotations than FlyBase.

GO Summary Ribbons

Expression Summary Ribbons

-0.38

Gene ToolKit

Disease Model Summary Ribbon

Report Sections