FlyBase Gene Report: Dmel\RabGGTb

General Information

Symbol

Dmel\RabGGTb

Species

D. melanogaster

Name

Rab geranylgeranyltransferase subunit beta

Annotation Symbol

CG18627

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028970

Gene Model Status

Current

Stock Availability

11 publicly available

Enzyme Name (EC)

protein geranylgeranyltransferase type II (2.5.1.60)

Gene Summary

Contributes to Rab geranylgeranyltransferase activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of Rab-protein geranylgeranyltransferase complex. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and head mesoderm. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta). (Alliance, FBgn0028970 )

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All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

βggt-II, betaggt-II

Key Links

Genomic Location

Cytogenetic map

23C1-23C1

Sequence location

2L:2,879,112..2,880,708 [+]

Recombination map

2-8

RefSeq locus

NT_033779 REGION:2879112..2880708

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

enzyme

regulator

receptor

receptor binding

transporter

structural molecule

cytoskeletal binding

DNA binding

RNA binding

transcription factor

small molecule binding

metal ion binding

lipid binding

carbohydrate binding

other molecular_function

molecular function

cell cycle/proliferation

cell organization/biogenesis

transport/localization

development

reproduction

immune system

nervous system process

behavior

response to stimulus

signaling

gene expression

protein metabolism

DNA metabolism

small molecule metabolism

other biological_process

biological process

extracellular region

cytosol

cytoskeleton

mitochondrion

nucleus

chromosome

membrane

cell periphery

cell junction

cell projection

endomembrane system

synapse

macromolecular complex

other cellular_component

cellular component

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

contributes_to Rab geranylgeranyltransferase activity

inferred from direct assay

(Charng et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

contributes_to Rab geranylgeranyltransferase activity

inferred from biological aspect of ancestor with PANTHER:PTN000206738

(GO Reference Genome Project, 2011-)

enables Rab geranylgeranyltransferase activity

inferred from electronic annotation with InterPro:IPR026873

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in endoplasmic reticulum to Golgi vesicle-mediated transport

inferred from biological aspect of ancestor with PANTHER:PTN000206738

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of Rab-protein geranylgeranyltransferase complex

inferred from direct assay

(Charng et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of Rab-protein geranylgeranyltransferase complex

inferred from biological aspect of ancestor with PANTHER:PTN000206738

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PROTEIN PRENYLTRANSFERASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

Rab geranylgeranyltransferase activity

geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L- cysteinyl-[protein] + diphosphate (2.5.1.60)

Summaries

Gene Model and Products

Expression Data

Gene ToolKit

The gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.

Category	Common alleles (# stocks)
Classical and Insertion Alleles
Loss of function allele
Amorphic allele
Fluorescently-tagged allele
Transgenic Constructs
UAS RNAi
UAS wild-type cDNA
Untagged genomic rescue
Fluorescently-tagged genomic rescue
Aberrations
Deficiency
Duplication

Alleles, Insertions, Transgenic Constructs, and Aberrations

Variants

Phenotypes

Orthologs

Paralogs

Human Disease Associations

Functional Complementation Data

Interactions

Pathways

Class of Gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-8

Cytogenetic map

23C1-23C1

Sequence location

2L:2,879,112..2,880,708 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

23C1-23C1

Limits computationally determined from genome sequence between P{PZ}oho23B⁰³⁵⁷⁵ and P{PZ}lilli⁰⁰⁶³²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

23C1-23C2

(Avedisov, 1999.3.5)

Experimentally Determined Recombination Data

Location

2-8

(FlyBase, 2016)

2-6.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Other Comments

Relationship to Other Genes

Nomenclature History

Synonyms and Secondary IDs (10)

Datasets (0)

External Crossreferences and Linkouts ( 38 )

References (37)

The following external sites may use different assemblies or annotations than FlyBase.

GO Summary Ribbons

Expression Summary Ribbons

2.42

Gene ToolKit

Disease Model Summary Ribbon

Report Sections