FlyBase Gene Report: Dmel\Sar1

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Gene: Dmel\Sar1

General Information

Symbol

Dmel\Sar1

Species

D. melanogaster

Name

Secretion-associated Ras-related 1

Annotation Symbol

CG7073

Feature Type

protein_coding_gene

FlyBase ID

FBgn0038947

Gene Model Status

Stock Availability

14 publicly available

Gene Summary

Secretion-associated Ras-related 1 (Sar1) encodes a small GTPase that is recruited to the endoplasmic reticulum and initiates the recruitment of the COPII subunit complex Sec23/Sec24. [Date last reviewed: 2018-11-08] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(3)05712, bro5

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:22,356,685..22,360,711 [+]

Recombination map

3-74

RefSeq locus

NT_033777 REGION:22356685..22360711

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

enzyme

regulator

receptor

receptor binding

transporter

structural molecule

cytoskeletal binding

DNA binding

RNA binding

transcription factor

small molecule binding

metal ion binding

lipid binding

carbohydrate binding

other molecular_function

molecular function

cell cycle/proliferation

cell organization/biogenesis

transport/localization

development

reproduction

immune system

nervous system process

behavior

response to stimulus

signaling

gene expression

protein metabolism

DNA metabolism

small molecule metabolism

other biological_process

biological process

extracellular region

cytosol

cytoskeleton

mitochondrion

nucleus

chromosome

membrane

cell periphery

cell junction

cell projection

endomembrane system

synapse

macromolecular complex

other cellular_component

cellular component

Gene Ontology (GO) Annotations (21 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables scaffold protein binding

inferred from physical interaction with FLYBASE:Sec16; FB:FBgn0052654

(Ivan et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables GTP binding

inferred from electronic annotation with InterPro:IPR006687, InterPro:IPR006689

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR005225, InterPro:IPR006687, InterPro:IPR006689

(InterPro Project Members, 2004-)

enables GTPase activity

inferred from sequence or structural similarity with SGD:S000006139

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR006689

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000195056

(GO Reference Genome Project, 2011-)

Biological Process (15 terms)

Terms Based on Experimental Evidence (11 terms)

CV Term

Evidence

References

acts_upstream_of_positive_effect chitin-based cuticle development

inferred from mutant phenotype

(Norum et al., 2010)

involved_in chitin-based larval cuticle pattern formation

inferred from mutant phenotype

(Abrams and Andrew, 2005)

involved_in COPII vesicle coating

inferred from mutant phenotype

(Ivan et al., 2008)

involved_in embryonic heart tube development

inferred from mutant phenotype

(Yi et al., 2006)

involved_in endoplasmic reticulum to Golgi vesicle-mediated transport

inferred from mutant phenotype

(Norum et al., 2010)

involved_in host-mediated suppression of symbiont invasion

inferred from high throughput mutant phenotype

(Hodgson et al., 2019)

involved_in larval chitin-based cuticle development

inferred from mutant phenotype

(Abrams and Andrew, 2005)

involved_in mitochondrial membrane organization

inferred from mutant phenotype

(Maddison et al., 2023)

involved_in positive regulation of dendrite morphogenesis

inferred from mutant phenotype

(Ye et al., 2007)

involved_in positive regulation of synapse pruning

inferred from mutant phenotype

(Wang et al., 2018)

involved_in protein localization to plasma membrane

inferred from mutant phenotype

(Kumichel et al., 2015)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in endoplasmic reticulum to Golgi vesicle-mediated transport

inferred from biological aspect of ancestor with PANTHER:PTN000195056

(GO Reference Genome Project, 2011-)

involved_in intracellular protein transport

inferred from electronic annotation with InterPro:IPR006687

(InterPro Project Members, 2004-)

involved_in membrane organization

inferred from biological aspect of ancestor with PANTHER:PTN000195056

(GO Reference Genome Project, 2011-)

involved_in regulation of COPII vesicle coating

inferred from sequence or structural similarity with SGD:S000006139

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000195056

(GO Reference Genome Project, 2011-)

involved_in vesicle organization

inferred from biological aspect of ancestor with PANTHER:PTN000195056

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in endoplasmic reticulum exit site

inferred from direct assay

(Ivan et al., 2008)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of COPII vesicle coat

inferred from biological aspect of ancestor with PANTHER:PTN000195056

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with SGD:S000006139

(Gene Ontology Curators, 2002-)

is_active_in endoplasmic reticulum exit site

inferred from biological aspect of ancestor with PANTHER:PTN000195056

(GO Reference Genome Project, 2011-)

located_in mitochondria-associated endoplasmic reticulum membrane contact site

inferred from sequence or structural similarity with UniProtKB:P20606

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

COAT PROTEIN COMPLEX II

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

GTPase activity
RHEA 19669:

Summaries

Gene Model and Products

Expression Data

Gene ToolKit

The gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.

Category	Common alleles (# stocks)
Classical and Insertion Alleles
Loss of function allele
Amorphic allele
Fluorescently-tagged allele
Transgenic Constructs
UAS RNAi
UAS wild-type cDNA
Untagged genomic rescue
Fluorescently-tagged genomic rescue
Aberrations
Deficiency
Duplication

Alleles, Insertions, Transgenic Constructs, and Aberrations

Variants

Phenotypes

Orthologs

Paralogs

Human Disease Associations

Functional Complementation Data

Interactions

Pathways

Class of Gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-74

Cytogenetic map

Sequence location

3R:22,356,685..22,360,711 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

94A5-94A6

Limits computationally determined from genome sequence between P{lacW}how^j5B5&P{EP}EP738 and P{lacW}l(3)L3560^L3560

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

94A3-94A4

(determined by in situ hybridisation)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-74

(FlyBase, 2016)

3-77.0

(Comeron et al., 2012)

2-

(Rabouille, 2000.3.15)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Other Comments

Relationship to Other Genes

Nomenclature History

Synonyms and Secondary IDs (20)

Datasets (0)

External Crossreferences and Linkouts ( 60 )

References (145)