l(3)05712, bro5
Enables scaffold protein binding activity. Involved in several processes, including COPII vesicle coating; chitin-based larval cuticle pattern formation; and positive regulation of cellular component organization. Acts upstream of with a positive effect on chitin-based cuticle development. Located in endoplasmic reticulum exit site. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gland; and gut section. Human ortholog(s) of this gene implicated in chylomicron retention disease. Orthologous to human SAR1A (secretion associated Ras related GTPase 1A) and SAR1B (secretion associated Ras related GTPase 1B).
The gene Secretion-associated Ras-related 1 is referred to in FlyBase by the symbol Dmel\Sar1 (CG7073, FBgn0038947). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (1 unique). Gene sequence location is 3R:22356685..22360711. Its molecular function is described by: scaffold protein binding; GTPase activity; GTP binding. It is involved in the biological process described with 15 unique terms, many of which group under: protein localization to membrane; innate immune response; regulation of synapse organization; cellular macromolecule localization; cell morphogenesis. 22 alleles are reported. The phenotypes of these alleles manifest in: cellular anatomical structure; membraneless organelle; mesodermal derivative; larval peripheral nervous system; intracellular anatomical structure. The phenotypic classes of alleles include: increased mortality; abnormal cell cycle; abnormal cell number; phenotype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.
Please see the JBrowse view of Dmel\Sar1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.43
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sar1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\Sar1 in JBrowseThe gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.
Category | Common alleles (# stocks) |
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Classical and Insertion Alleles | |
Loss of function allele | |
Amorphic allele | |
Fluorescently-tagged allele | |
Transgenic Constructs | |
UAS RNAi | |
UAS wild-type cDNA | |
Untagged genomic rescue | |
Fluorescently-tagged genomic rescue | |
Aberrations | |
Deficiency | |
Duplication |
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mutants have reduced dendritic arbors but normal axonal growth in the class IV dendritic arborization (da) neurons.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
Source for merge of: sar1 l(3)05712
Source for merge of: sar1 anon- EST:Liang-1.48
Source for identity of sar1 CG7073 was sequence comparison ( date:000327 ).
Source for merge of sar1 anon- EST:Liang-1.48 was sequence comparison ( date:030722 ).
Source for identity of: sar1 CG7073
Source for identity of: Sar1 sar1
Named "Sar1" after the S. cerevisiae ortholog.