FB2025_01 , released February 20, 2025
Gene: Dmel\sens-2
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General Information
Symbol
Dmel\sens-2
Species
D. melanogaster
Name
senseless-2
Annotation Symbol
CG31632
Feature Type
protein_coding_gene
FlyBase ID
FBgn0051632
Gene Model Status
Current
Stock Availability
20 publicly available
Gene Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic midgut chamber; embryonic/larval midgut; and posterior midgut primordium. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gray platelet syndrome; myelodysplastic syndrome; platelet-type bleeding disorder 17; and severe congenital neutropenia 2. Orthologous to several human genes including GFI1B (growth factor independent 1B transcriptional repressor). (Alliance, FBgn0051632 )
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All Summaries
Also Known As

sens2

Key Links
Genomic Location
Cytogenetic map
27B4-27B4
Sequence location
Recombination map
2-22
RefSeq locus
NT_033779 REGION:6821934..6838995
Sequence
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Function

GO Summary Ribbons

enzyme
regulator
receptor
receptor binding
transporter
structural molecule
cytoskeletal binding
DNA binding
RNA binding
transcription factor
small molecule binding
metal ion binding
lipid binding
carbohydrate binding
other molecular_function
molecular function
cell cycle/proliferation
cell organization/biogenesis
transport/localization
development
reproduction
immune system
nervous system process
behavior
response to stimulus
signaling
gene expression
protein metabolism
DNA metabolism
small molecule metabolism
other biological_process
biological process
extracellular region
cytosol
cytoskeleton
mitochondrion
nucleus
chromosome
membrane
cell periphery
cell junction
cell projection
endomembrane system
synapse
macromolecular complex
other cellular_component
cellular component
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (2 terms)
Biological Process (1 term)
Cellular Component (1 term)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Expression Data

Gene ToolKit

Alleles, Insertions, Transgenic Constructs, and Aberrations
Variants
Phenotypes
Orthologs
Paralogs
Human Disease Associations
Functional Complementation Data
Interactions
Pathways
Class of Gene
Genomic Location and Detailed Mapping Data
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Other Comments
Relationship to Other Genes
Nomenclature History
Synonyms and Secondary IDs (8)
Datasets (0)
External Crossreferences and Linkouts ( 35 )
References (49)